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1: Radiat Res. 2001 Jan;155(1 Pt 2):194-200.
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Alternative lengthening of telomeres in human cells.

Reddel RR, Bryan TM, Colgin LM, Perrem KT, Yeager TR.

Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, New South Wales, 2145 Australia.

Activation of a telomere maintenance mechanism appears to be essential for immortalization. In most human tumors and tumor cell lines, the telomere maintenance mechanism involves the activity of telomerase, a reverse transcriptase holoenzyme that synthesizes telomeric repeat DNA. In some cases, telomere maintenance occurs in the absence of telomerase activity by a mechanism referred to as alternative lengthening of telomeres (ALT). The development of telomere-targeted anticancer therapies will be facilitated by an understanding of the molecular mechanisms of ALT and of the means whereby ALT is repressed in normal cells.

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PMID: 11121234 [PubMed - indexed for MEDLINE]